Generation of human nucleus pulposus cells from stem cells: First steps towards intervertebral disc regeneration.
نویسندگان
چکیده
منابع مشابه
The generation and functional characterization of induced pluripotent stem cells from human intervertebral disc nucleus pulposus cells
Disc degenerative disease (DDD) is believed to originate in the nucleus pulposus (NP) region therefore, it is important to obtain a greater number of active NP cells for the study and therapy of DDD. Human induced pluripotent stem cells (iPSCs) are a powerful tool for modeling the development of DDD in humans, and have the potential to be applied in regenerative medicine. NP cells were isolated...
متن کاملCharacteristics and potentials of stem cells derived from human degenerated nucleus pulposus: potential for regeneration of the intervertebral disc
BACKGROUND Eliminating the symptoms during treatment of intervertebral disc degeneration (IVDD) is only a temporary solution that does not cure the underlying cause. A biological method to treat this disorder may be possible by the newly discovered nucleus pulposus derived stem cells (NPDCs). However, the uncertain characteristics and potential of NPDCs calls for a comprehensive study. METHOD...
متن کاملCo-culture of Adult Mesenchymal Stem Cells and Nucleus Pulposus Cells in Bilaminar Pellets for Intervertebral Disc Regeneration
BACKGROUND Our goal is to optimize stem cell-based tissue engineering strategies in the context of the intervertebral disc environment. We explored the benefits of co-culturing nucleus pulposus cells (NPC) and adult mesenchymal stem cells (MSC) using a novel spherical bilaminar pellet culture system where one cell type is enclosed in a sphere of the other cell type. Our 3D system provides a str...
متن کاملAdipose Stem Cells and Intervertebral Disc Regeneration:
General Abstract Current treatments for the degenerated intervertebral disc (IVD) comprise pain management and invasive surgical interventions; both of them are aimed at relieving the pain instead of repairing the tissue and restoring the biological function of the disc. Cell-based tissue engineering may meet the clinical need for the repair or regeneration of a damaged tissue, and it might be ...
متن کاملEffect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration
INTRODUCTION Early degenerative changes in the nucleus pulposus (NP) are observed after the disappearance of notochordal cells (NCs). Thus, it has been suggested that NCs play an important role in maintaining the NP and may have a regenerative potential on other cells of the NP. As the number of resident NP cells (NPCs) decreases in a degenerating disc, mesenchymal stromal (stem) cells (MSCs) m...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2016
ISSN: 1063-4584
DOI: 10.1016/j.joca.2016.01.051